Male be a carrier for sex linked disease

Dyskeratosis congenita Hypohidrotic ectodermal dysplasia EDA X-linked ichthyosis X-linked endothelial corneal dystrophy. In contrast, a female must inherit two mutant alleles, a less frequent event since the mutant allele is rare in the population. If the mother is not a carrier, no male children of an affected father will be affected, as males only inherit their father's Y-chromosome.

Pediatric Dermatology and Dermatopathology: This means that in a person with two X chromosomes most femalesboth copies of a gene i. Review provided by VeriMed Healthcare Network. Alport syndrome Dent's disease X-linked nephrogenic diabetes insipidus. This is caused by a mutation in a gene on the X chromosome called F8.

Female carriers can have a normal X chromosome that is abnormally inactivated. If only one gene in the pair is abnormal, the disease does not occur or it is mild. Most human cells have 46 chromosomes that provide the genetic instructions for a body to live, grow, and develop.