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Because of that, it doesn't protect the male. If the mother is not a carrier, no male children of an affected father will be affected, as males only inherit their father's Y-chromosome.

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Closely linked genes on autosomes called " supergenes " are often responsible for the latter. Breeding experiments with Lepidoptera. Each daughter born to a affected father and a non-carrier mother will be a carrier.

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X-linked recessive traits are expressed in all heterogametics, but are only expressed in those homogametics that are homozygous for the recessive allele. Textbook of Family Medicine. However, X-linked recessive diseases can occur in both males and females.

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In mammals , the female is homogametic, with two X chromosomes XX , while the male is the heterogametic sex , with one X and one Y chromosome XY. Female carriers can have a normal X chromosome that is abnormally inactivated.